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MENDEL is a set of Fortran 77 routines for the genetic analysis of human pedigree data. Its use is well established for segregation analysis, linkage calculations and genetic counseling. A detailed description of the algorithms is provided in Lange et al, 1988. Users can also consult other papers by Lange and colleagues (Lange and Elston 1975; Lange and Boehnke, 1983; Lange and Goradia, 1987; Goradia et al, 1992) for the theoretical background.
Cyrillic incorporates a version of MENDEL which performs likelihood calculations for conditions with age-dependent penetrance. MENDEL automatically handles both inbreeding and monozygous twinning.
As standard, Cyrillic is provided with penetrance tables for predisposition to breast/ovarian cancer based on Claus population frequencies (Claus et al, 1996). It is however possible to input ones own population data (penetrances, prior probabilities of genotypes), and to use MENDEL for other disorders. An option to use the Gompertz function for penetrances as an alternative to penetrance tables.
Examples for using MENDEL are provided in the Cyrillic manual. The Help files also contain more information.
Cyrillic uses the version of MENDEL developed by Ken Lange and colleagues. The developer assumes no legal liability for use of the software or algorithms.
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